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KMID : 0043319920150040343
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Archives of Pharmacal Research
1992 Volume.15 No. 4 p.343 ~ p.346
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A Synthetic Study on Cyclic Phosphate Derivatives of Seconucleosides as Potential Antiviral Agents (II): Synthesis of 3’,5’-Cyclic Phosphates of 6-aza-2’-azido-secouridine
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Shin DH
Yang JW/Kim JH/Lee CK/Chung WK/Chun MW
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Abstract
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The synthesis of 6-aza-3’,5’-p-nitrophenylphosphoryltrioxy-2’-azido-2’-deoxy-2’,3’-secouridine and 6-aza-3’,5’-phosphoryltrioxy-2’-azido-2’-deoxy-2’,3’-secouridine ammonium salt are described and they were evaluated for antiviral activity primarily against DNA and RNA viruses and found to be inactive. But no significant cytocidal effect was observed against Vcro and Hela cell.
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KEYWORD
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